Evaluation of Non Enzymatic Status in Antioxidant Capital in Senegalese Type 2 Diabetics

Oxidative stress appears very early in the history of type 2 diabetes complications. It is associated to glucose oxidation but also lipid peroxidation. This can be accentuated by a decrease antioxidant capacities diabetics, especially if there are other comorbidities. The objective this study was evaluate capacity Senegalese diabetics and identify risk factors.
 We conducted prospective 40 persons with diabetes. Factors related age, sex, BMI, BP were determined. For biological parameters, we measured blood at empty stomach, glycated haemoglobin, total cholesterol, HDL, triglycerides LDL, urea creatinine, uric acid, albumin, bilirubin, copper, zinc.
 mean age population 58±11.24 years predominance subjects aged over 60 (52.5%). sex ratio 1.11 52.5% male. Antioxidant capital reduced 60% patients, women (35%). reduction marked hypoalbuminemia (32.5%), hypozincemia (22.5) an increase Cu/Zn (30%). A strong correlation found between cholesterol (r=0.911; p<0.0001) as well LDL (r=1; p=0.0001). Dyslipidaemia most comorbidity decreased oxidative RR 1.4 (CI=0.79-2.35) for hypercholesterolemia 1.6 (CI=0.75-3.71) hypertriglyceridemia.
 dyslipidaemia conditions. Hygienic dietary measures supplementation trace elements such zinc should prevent complications diabetics.